D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Sandra Weimer, Josephine Priebs, Doreen Kuhlow, Marco Groth, Steffen Priebe, Johannes Mansfeld, Troy L. Merry, Sébastien Dubuis, Beate Laube, Andreas F. Pfeiffer, Tim J. Schulz, Reinhard Guthke, Matthias Platzer, Nicola Zamboni, Kim Zarse and Michael Ristow ()
Additional contact information
Sandra Weimer: Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich)
Josephine Priebs: Institute of Nutrition, University of Jena
Doreen Kuhlow: German Institute of Human Nutrition Potsdam-Rehbrücke
Marco Groth: Genome Analysis Group, Leibniz Institute for Age Research, Fritz-Lipmann-Institute
Steffen Priebe: Systems Biology and Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute
Johannes Mansfeld: Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich)
Troy L. Merry: Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich)
Sébastien Dubuis: Institute of Molecular Systems Biology, ETH Zürich (Swiss Federal Institute of Technology Zurich)
Beate Laube: Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich)
Andreas F. Pfeiffer: German Institute of Human Nutrition Potsdam-Rehbrücke
Tim J. Schulz: German Institute of Human Nutrition Potsdam-Rehbrücke
Reinhard Guthke: Systems Biology and Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute
Matthias Platzer: Genome Analysis Group, Leibniz Institute for Age Research, Fritz-Lipmann-Institute
Nicola Zamboni: Institute of Molecular Systems Biology, ETH Zürich (Swiss Federal Institute of Technology Zurich)
Kim Zarse: Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich)
Michael Ristow: Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich)

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that activates AMP-activated protein kinase (AMPK/AAK-2) and increases mitochondrial biogenesis. Consistent with the concept of mitohormesis, GlcN promotes increased formation of mitochondrial reactive oxygen species (ROS) culminating in increased expression of the nematodal amino acid-transporter 1 (aat-1) gene. Ameliorating mitochondrial ROS formation or impairment of aat-1-expression abolishes GlcN-mediated life span extension in an NRF2/SKN-1-dependent fashion. Unlike other calorie restriction mimetics, such as 2-deoxyglucose, GlcN extends life span of ageing C57BL/6 mice, which show an induction of mitochondrial biogenesis, lowered blood glucose levels, enhanced expression of several murine amino-acid transporters, as well as increased amino-acid catabolism. Taken together, we provide evidence that GlcN extends life span in evolutionary distinct species by mimicking a low-carbohydrate diet.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms4563 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4563

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4563

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().