Cell wall precursors are required to organize the chlamydial division septum

Nicolas Jacquier, Antonio Frandi, Trestan Pillonel, Patrick H. Viollier and Gilbert Greub ()
Additional contact information
Nicolas Jacquier: Institute of Microbiology, University Hospital Center and University of Lausanne
Antonio Frandi: Institute of Genetics & Genomics in Geneva (iGE3), Faculty of Medicine / CMU, University of Geneva
Trestan Pillonel: Institute of Microbiology, University Hospital Center and University of Lausanne
Patrick H. Viollier: Institute of Genetics & Genomics in Geneva (iGE3), Faculty of Medicine / CMU, University of Geneva
Gilbert Greub: Institute of Microbiology, University Hospital Center and University of Lausanne

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract Members of the Chlamydiales order are major bacterial pathogens that divide at mid-cell, without a sequence homologue of the FtsZ cytokinetic tubulin and without a classical peptidoglycan cell wall. Moreover, the spatiotemporal mechanisms directing constriction in Chlamydia are not known. Here we show that the MreB actin homologue and its conserved regulator RodZ localize to the division furrow in Waddlia chondrophila, a member of the Chlamydiales order implicated in human miscarriage. RodZ is recruited to the septal site earlier than MreB and in a manner that depends on biosynthesis of the peptidoglycan precursor lipid II by the MurA enzyme. By contrast, crosslinking of lipid II peptides by the Pbp3 transpeptidase disperses RodZ from the septum. Altogether, these findings provide a cytological framework for understanding chlamydial cytokinesis driven by septal cell wall synthesis.

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms4578 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4578

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4578

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().