Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

Byung Cheon Lee, Alaattin Kaya, Siming Ma, Gwansu Kim, Maxim V. Gerashchenko, Sun Hee Yim, Zhen Hu, Lawrence G. Harshman and Vadim N. Gladyshev ()
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Byung Cheon Lee: Brigham & Women’s Hospital and Harvard Medical School
Alaattin Kaya: Brigham & Women’s Hospital and Harvard Medical School
Siming Ma: Brigham & Women’s Hospital and Harvard Medical School
Gwansu Kim: Korea University
Maxim V. Gerashchenko: Brigham & Women’s Hospital and Harvard Medical School
Sun Hee Yim: Brigham & Women’s Hospital and Harvard Medical School
Zhen Hu: School of Biological Sciences, University of Nebraska-Lincoln
Lawrence G. Harshman: School of Biological Sciences, University of Nebraska-Lincoln
Vadim N. Gladyshev: Brigham & Women’s Hospital and Harvard Medical School

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.

Date: 2014
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DOI: 10.1038/ncomms4592

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