Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labelling

Nobuhiko Miyasaka (), Ignacio Arganda-Carreras, Noriko Wakisaka, Miwa Masuda, Uygar Sümbül, H. Sebastian Seung and Yoshihiro Yoshihara ()
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Nobuhiko Miyasaka: RIKEN Brain Science Institute
Ignacio Arganda-Carreras: Massachusetts Institute of Technology
Noriko Wakisaka: RIKEN Brain Science Institute
Miwa Masuda: RIKEN Brain Science Institute
Uygar Sümbül: Massachusetts Institute of Technology
H. Sebastian Seung: Massachusetts Institute of Technology
Yoshihiro Yoshihara: RIKEN Brain Science Institute

Nature Communications, 2014, vol. 5, issue 1, 1-14

Abstract: Abstract Chemotopic odour representations in the olfactory bulb are transferred to multiple forebrain areas and translated into appropriate output responses. However, a comprehensive projection map of bulbar output neurons at single-axon resolution is lacking in vertebrates. Here we unravel a projectome of the zebrafish olfactory bulb through genetic single-neuron tracing and image registration. We show that five major target regions receive distinct modes of projections from olfactory bulb glomeruli. The central portion of posterior telencephalon receives non-selective, interspersed inputs from all glomeruli, whereas the ventral telencephalon is diffusely innervated by axons from particular glomerular clusters. The right habenula and posterior tuberculum (diencephalic nuclei) receive convergent inputs from restricted and all glomerular clusters, respectively. The bulbar recurrent projections are coarsely topographic. Thus, the primary chemotopic organization is transformed into distinct sensory representations in higher olfactory centres. These findings provide a framework to understand general principles as well as species-specific features in decoding of odour information.

Date: 2014
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DOI: 10.1038/ncomms4639

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