Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells

Takeshi Yoshimatsu, Philip R. Williams, Florence D. D’Orazi, Sachihiro C. Suzuki, James M. Fadool, W. Ted Allison, Pamela A. Raymond and Rachel O. Wong ()
Additional contact information
Takeshi Yoshimatsu: University of Washington
Philip R. Williams: University of Washington
Florence D. D’Orazi: University of Washington
Sachihiro C. Suzuki: University of Washington
James M. Fadool: The Florida State University
W. Ted Allison: University of Alberta
Pamela A. Raymond: Cellular, and Developmental Biology, University of Michigan
Rachel O. Wong: University of Washington

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Many neurons receive synapses in stereotypic proportions from converging but functionally distinct afferents. However, developmental mechanisms regulating synaptic convergence are not well understood. Here we describe a heterotypic mechanism by which one afferent controls synaptogenesis of another afferent, but not vice versa. Like other CNS circuits, zebrafish retinal H3 horizontal cells (HC) undergo an initial period of remodelling, establishing synapses with ultraviolet and blue cones while eliminating red and green cone contacts. As development progresses, the HCs selectively synapse with ultraviolet cones to generate a 5:1 ultraviolet-to-blue cone synapse ratio. Blue cone synaptogenesis increases in mutants lacking ultraviolet cones, and when transmitter release or visual stimulation of ultraviolet cones is perturbed. Connectivity is unaltered when blue cone transmission is suppressed. Moreover, there is no cell-autonomous regulation of cone synaptogenesis by neurotransmission. Thus, biased connectivity in this circuit is established by an unusual activity-dependent, unidirectional control of synaptogenesis exerted by the dominant input.

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms4699 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4699

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4699

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().