Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Ran Namgung, Yeong Mi Lee, Jihoon Kim, Yuna Jang, Byung-Heon Lee, In-San Kim, Pandian Sokkar, Young Min Rhee, Allan S. Hoffman and Won Jong Kim ()
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Ran Namgung: Center for Self-assembly and Complexity, Institute for Basic Science
Yeong Mi Lee: Center for Self-assembly and Complexity, Institute for Basic Science
Jihoon Kim: Center for Self-assembly and Complexity, Institute for Basic Science
Yuna Jang: Center for Self-assembly and Complexity, Institute for Basic Science
Byung-Heon Lee: School of Medicine, Kyungpook National University
In-San Kim: School of Medicine, Kyungpook National University
Pandian Sokkar: Center for Self-assembly and Complexity, Institute for Basic Science
Young Min Rhee: Center for Self-assembly and Complexity, Institute for Basic Science
Allan S. Hoffman: University of Washington
Won Jong Kim: Center for Self-assembly and Complexity, Institute for Basic Science

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host–guest interactions between a polymer–cyclodextrin conjugate and a polymer–paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

Date: 2014
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DOI: 10.1038/ncomms4702

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