Generation of colonic IgA-secreting cells in the caecal patch

Kazunori Masahata, Eiji Umemoto, Hisako Kayama, Manato Kotani, Shota Nakamura, Takashi Kurakawa, Junichi Kikuta, Kazuyoshi Gotoh, Daisuke Motooka, Shintaro Sato, Tomonori Higuchi, Yoshihiro Baba, Tomohiro Kurosaki, Makoto Kinoshita, Yosuke Shimada, Taishi Kimura, Ryu Okumura, Akira Takeda, Masaru Tajima, Osamu Yoshie, Masahiro Fukuzawa, Hiroshi Kiyono, Sidonia Fagarasan, Tetsuya Iida, Masaru Ishii and Kiyoshi Takeda ()
Additional contact information
Kazunori Masahata: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Eiji Umemoto: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Hisako Kayama: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Manato Kotani: Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Shota Nakamura: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita
Takashi Kurakawa: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Junichi Kikuta: Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Kazuyoshi Gotoh: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita
Daisuke Motooka: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita
Shintaro Sato: Institute of Medical Science, The University of Tokyo
Tomonori Higuchi: Kinki University Faculty of Medicine, Osaka-Sayama
Yoshihiro Baba: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita
Tomohiro Kurosaki: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita
Makoto Kinoshita: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Yosuke Shimada: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Taishi Kimura: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Ryu Okumura: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Akira Takeda: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita
Masaru Tajima: The Institute of Experimental Animal Sciences, Faculty of Medicine, Osaka University, Suita
Osamu Yoshie: Kinki University Faculty of Medicine, Osaka-Sayama
Masahiro Fukuzawa: Graduate School of Medicine, Osaka University, Suita
Hiroshi Kiyono: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Sidonia Fagarasan: Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN
Tetsuya Iida: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita
Masaru Ishii: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Kiyoshi Takeda: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Suita

Nature Communications, 2014, vol. 5, issue 1, 1-13

Abstract: Abstract Gut-associated lymphoid tissues are responsible for the generation of IgA-secreting cells. However, the function of the caecal patch, a lymphoid tissue in the appendix, remains unknown. Here we analyse the role of the caecal patch using germ-free mice colonized with intestinal bacteria after appendectomy. Appendectomized mice show delayed accumulation of IgA+ cells in the large intestine, but not the small intestine, after colonization. Decreased colonic IgA+ cells correlate with altered faecal microbiota composition. Experiments using photoconvertible Kaede-expressing mice or adoptive transfer show that the caecal patch IgA+ cells migrate to the large and small intestines, whereas Peyer’s patch cells are preferentially recruited to the small intestine. IgA+ cells in the caecal patch express higher levels of CCR10. Dendritic cells in the caecal patch, but not Peyer’s patches, induce CCR10 on cocultured B cells. Thus, the caecal patch is a major site for generation of IgA-secreting cells that migrate to the large intestine.

Date: 2014
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DOI: 10.1038/ncomms4704

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