Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

Paula Dominguez-Salas, Sophie E. Moore, Maria S. Baker, Andrew W. Bergen, Sharon E. Cox, Roger A. Dyer, Anthony J. Fulford, Yongtao Guan, Eleonora Laritsky, Matt J. Silver, Gary E. Swan, Steven H. Zeisel, Sheila M. Innis, Robert A. Waterland (), Andrew M. Prentice and Branwen J. Hennig ()
Additional contact information
Paula Dominguez-Salas: MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street
Sophie E. Moore: MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street
Maria S. Baker: Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center
Andrew W. Bergen: Center for Health Sciences, SRI International
Sharon E. Cox: MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street
Roger A. Dyer: University of British Columbia
Anthony J. Fulford: MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street
Yongtao Guan: Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center
Eleonora Laritsky: Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center
Matt J. Silver: MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street
Gary E. Swan: Stanford Prevention Research Center, Stanford University School of Medicine
Steven H. Zeisel: Nutrition Research Institute, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill
Sheila M. Innis: University of British Columbia
Robert A. Waterland: Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center
Andrew M. Prentice: MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street
Branwen J. Hennig: MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.

Date: 2014
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DOI: 10.1038/ncomms4746

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