IL-21 induces IL-22 production in CD4+ T cells

Ada Yeste, Ivan D. Mascanfroni, Meghan Nadeau, Evan J. Burns, Ann-Marcia Tukpah, Andrezza Santiago, Chuan Wu, Bonny Patel, Deepak Kumar and Francisco J Quintana ()
Additional contact information
Ada Yeste: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Ivan D. Mascanfroni: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Meghan Nadeau: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Evan J. Burns: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Ann-Marcia Tukpah: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Andrezza Santiago: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Chuan Wu: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Bonny Patel: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Deepak Kumar: Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Francisco J Quintana: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School

Nature Communications, 2014, vol. 5, issue 1, 1-13

Abstract: Abstract Interleukin (IL)-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We investigated the regulation IL-22 production by CD4+ T cells. Here we show that IL-21 triggers IL-22, but not IL-17 production by CD4+ T cells. STAT3, activated by IL-21, controls the epigenetic status of the il22 promoter and its interaction with the aryl hydrocarbon receptor (AhR). Moreover, IL-21 and AhR signalling in T cells control IL-22 production and the development of dextran sodium sulphate-induced colitis in ILC-deficient mice. Thus, we have identified IL-21 as an inducer of IL-22 production in CD4+ T cells in vitro and in vivo.

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms4753 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4753

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4753

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().