Translation-independent circadian control of the cell cycle in a unicellular photosynthetic eukaryote

Shin-ya Miyagishima (), Takayuki Fujiwara, Nobuko Sumiya, Shunsuke Hirooka, Akihiko Nakano, Yukihiro Kabeya and Mami Nakamura
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Shin-ya Miyagishima: Center for Frontier Research, National Institute of Genetics
Takayuki Fujiwara: Center for Frontier Research, National Institute of Genetics
Nobuko Sumiya: Center for Frontier Research, National Institute of Genetics
Shunsuke Hirooka: Center for Frontier Research, National Institute of Genetics
Akihiko Nakano: Live Cell Molecular Imaging Research Team, RIKEN Center for Advanced Photonics
Yukihiro Kabeya: Center for Frontier Research, National Institute of Genetics
Mami Nakamura: Center for Frontier Research, National Institute of Genetics

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract Circadian rhythms of cell division have been observed in several lineages of eukaryotes, especially photosynthetic unicellular eukaryotes. However, the mechanism underlying the circadian regulation of the cell cycle and the nature of the advantage conferred remain unknown. Here, using the unicellular red alga Cyanidioschyzon merolae, we show that the G1/S regulator RBR-E2F-DP complex links the G1/S transition to circadian rhythms. Time-dependent E2F phosphorylation promotes the G1/S transition during subjective night and this phosphorylation event occurs independently of cell cycle progression, even under continuous dark or when cytosolic translation is inhibited. Constitutive expression of a phospho-mimic of E2F or depletion of RBR unlinks cell cycle progression from circadian rhythms. These transgenic lines are exposed to higher oxidative stress than the wild type. Circadian inhibition of cell cycle progression during the daytime by RBR-E2F-DP pathway likely protects cells from photosynthetic oxidative stress by temporally compartmentalizing photosynthesis and cell cycle progression.

Date: 2014
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DOI: 10.1038/ncomms4807

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