Magnetophoretic circuits for digital control of single particles and cells

Byeonghwa Lim, Venu Reddy, XingHao Hu, KunWoo Kim, Mital Jadhav, Roozbeh Abedini-Nassab, Young-Woock Noh, Yong Taik Lim, Benjamin B. Yellen () and CheolGi Kim ()
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Byeonghwa Lim: Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Venu Reddy: Daegu Gyeongbuk Institute of Science and Technology (DGIST)
XingHao Hu: Daegu Gyeongbuk Institute of Science and Technology (DGIST)
KunWoo Kim: Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Mital Jadhav: School of Engineering, Chungnam National University
Roozbeh Abedini-Nassab: Duke University
Young-Woock Noh: School of Engineering, Chungnam National University
Yong Taik Lim: SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University
Benjamin B. Yellen: Duke University
CheolGi Kim: Daegu Gyeongbuk Institute of Science and Technology (DGIST)

Nature Communications, 2014, vol. 5, issue 1, 1-10

Abstract: Abstract The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.

Date: 2014
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DOI: 10.1038/ncomms4846

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