Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men

Zhibin Hu (), Zheng Li, Jun Yu, Chao Tong, Yuan Lin, Xuejiang Guo, Feng Lu, Jing Dong, Yankai Xia, Yang Wen, Hao Wu, Honggang Li, Yong Zhu, Ping Ping, Xiangfeng Chen, Juncheng Dai, Yue Jiang, Shandong Pan, Peng Xu, Kailing Luo, Qiang Du, Bing Yao, Ming Liang, Yaoting Gui, Ning Weng, Hui Lu, Zhuqing Wang, Fengbin Zhang, Xiaobin Zhu, Xiaoyu Yang, Zhou Zhang, Han Zhao, Chenliang Xiong, Hongxia Ma, Guangfu Jin, Feng Chen, Jianfeng Xu, Xinru Wang, Zuomin Zhou, Zi-Jiang Chen (), Jiayin Liu (), Hongbing Shen and Jiahao Sha ()
Additional contact information
Zhibin Hu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Zheng Li: Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Jun Yu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Chao Tong: Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University
Yuan Lin: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Xuejiang Guo: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Feng Lu: School of Public Health, Nanjing Medical University
Jing Dong: School of Public Health, Nanjing Medical University
Yankai Xia: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Yang Wen: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Hao Wu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Honggang Li: Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology
Yong Zhu: Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Ping Ping: Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Xiangfeng Chen: Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Juncheng Dai: School of Public Health, Nanjing Medical University
Yue Jiang: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Shandong Pan: School of Public Health, Nanjing Medical University
Peng Xu: Jinghua Hospital, Shenyang Dongfang Medical Group
Kailing Luo: Reproductive Medical Center, The Second Hospital of Nanning
Qiang Du: Shengjing Hospital, China Medical University
Bing Yao: Nanjing Jinling Hospital
Ming Liang: The Second Affiliated Hospital, Shandong University of Traditional Chinese Medicine
Yaoting Gui: Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, FuTian District
Ning Weng: Jinghua Hospital, Shenyang Dongfang Medical Group
Hui Lu: Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Zhuqing Wang: Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Fengbin Zhang: The Women’s Hospital, School of Medicine, Zhejiang University
Xiaobin Zhu: Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Xiaoyu Yang: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Zhou Zhang: Maternal and Child Health Hospital of Shanxi Province
Han Zhao: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University
Chenliang Xiong: Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology
Hongxia Ma: School of Public Health, Nanjing Medical University
Guangfu Jin: School of Public Health, Nanjing Medical University
Feng Chen: School of Public Health, Nanjing Medical University
Jianfeng Xu: Huashan Hospital, Fudan University
Xinru Wang: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Zuomin Zhou: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Zi-Jiang Chen: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University
Jiayin Liu: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Hongbing Shen: State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Jiahao Sha: State Key Laboratory of Reproductive Medicine, Nanjing Medical University

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract Male factor infertility affects one-sixth of couples worldwide, and non-obstructive azoospermia (NOA) is one of the most severe forms. Our previous genome-wide association study (GWAS) identified three susceptibility loci for NOA in Han Chinese men. Here we test promising associations in an extended three-stage validation using 3,608 NOA cases and 5,909 controls to identify additional risk loci. We find strong evidence of three NOA susceptibility loci (P

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms4857 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4857

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4857

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().