Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production

Christopher J. Hall, Rachel H. Boyle, Xueying Sun, Sophie M. Wicker, June P Misa, Geoffrey W. Krissansen, Cristin G. Print, Kathryn E. Crosier and Philip S. Crosier ()
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Christopher J. Hall: School of Medical Sciences, University of Auckland
Rachel H. Boyle: School of Medical Sciences, University of Auckland
Xueying Sun: School of Medical Sciences, University of Auckland
Sophie M. Wicker: School of Medical Sciences, University of Auckland
June P Misa: School of Medical Sciences, University of Auckland
Geoffrey W. Krissansen: School of Medical Sciences, University of Auckland
Cristin G. Print: School of Medical Sciences, University of Auckland
Kathryn E. Crosier: School of Medical Sciences, University of Auckland
Philip S. Crosier: School of Medical Sciences, University of Auckland

Nature Communications, 2014, vol. 5, issue 1, 1-17

Abstract: Abstract In addition to satisfying the metabolic demands of cells, mitochondrial metabolism helps regulate immune cell function. To date, such cell-intrinsic metabolic-immunologic cross-talk has only been described operating in cells of the immune system. Here we show that epidermal cells utilize fatty acid β-oxidation to fuel their contribution to the immune response during cutaneous inflammation. By live imaging metabolic and immunological processes within intact zebrafish embryos during cutaneous inflammation, we uncover a mechanism where elevated β-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment. This mechanism requires the activity of a zebrafish homologue of the mammalian mitochondrial enzyme, Immunoresponsive gene 1. This study describes the first example of metabolic reprogramming operating within a non-immune cell type to help control its contribution to the immune response. Targeting of this metabolic–immunologic interface within keratinocytes may prove useful in treating inflammatory dermatoses.

Date: 2014
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DOI: 10.1038/ncomms4880

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