High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model

Jun Ma, Amanda L. Prince, David Bader, Min Hu, Radhika Ganu, Karalee Baquero, Peter Blundell, R. Alan Harris, Antonio E. Frias, Kevin L. Grove and Kjersti M. Aagaard ()
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Jun Ma: Departments of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Baylor College of Medicine and Texas Children’s Hospital
Amanda L. Prince: Departments of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Baylor College of Medicine and Texas Children’s Hospital
David Bader: Departments of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Baylor College of Medicine and Texas Children’s Hospital
Min Hu: Departments of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Baylor College of Medicine and Texas Children’s Hospital
Radhika Ganu: Departments of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Baylor College of Medicine and Texas Children’s Hospital
Karalee Baquero: Oregon National Primate Research Center, Oregon Health & Science University
Peter Blundell: Oregon National Primate Research Center, Oregon Health & Science University
R. Alan Harris: Departments of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Baylor College of Medicine and Texas Children’s Hospital
Antonio E. Frias: Oregon National Primate Research Center, Oregon Health & Science University
Kevin L. Grove: Oregon National Primate Research Center, Oregon Health & Science University
Kjersti M. Aagaard: Departments of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine at Baylor College of Medicine and Texas Children’s Hospital

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract The intestinal microbiome is a unique ecosystem and an essential mediator of metabolism and obesity in mammals. However, studies investigating the impact of the diet on the establishment of the gut microbiome early in life are generally lacking, and most notably so in primate models. Here we report that a high-fat maternal or postnatal diet, but not obesity per se, structures the offspring’s intestinal microbiome in Macaca fuscata (Japanese macaque). The resultant microbial dysbiosis is only partially corrected by a low-fat, control diet after weaning. Unexpectedly, early exposure to a high-fat diet diminished the abundance of non-pathogenic Campylobacter in the juvenile gut, suggesting a potential role for dietary fat in shaping commensal microbial communities in primates. Our data challenge the concept of an obesity-causing gut microbiome and rather provide evidence for a contribution of the maternal diet in establishing the microbiota, which in turn affects intestinal maintenance of metabolic health.

Date: 2014
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DOI: 10.1038/ncomms4889

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