Construction of RNA nanocages by re-engineering the packaging RNA of Phi29 bacteriophage

Chenhui Hao, Xiang Li, Cheng Tian, Wen Jiang, Guansong Wang () and Chengde Mao ()
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Chenhui Hao: Purdue University
Xiang Li: Purdue University
Cheng Tian: Purdue University
Wen Jiang: Markey Center for Structural Biology, Purdue University
Guansong Wang: The Institute of Respiratory Diseases, Xinqiao Hospital
Chengde Mao: Purdue University

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract RNA nanotechnology promises rational design of RNA nanostructures with wide array of structural diversities and functionalities. Such nanostructures could be used in applications such as small interfering RNA delivery and organization of in vivo chemical reactions. Though having impressive development in recent years, RNA nanotechnology is still quite limited and its programmability and complexity could not rival the degree of its closely related cousin: DNA nanotechnology. Novel strategies are needed for programmed RNA self-assembly. Here, we have assembled RNA nanocages by re-engineering a natural, biological RNA motif: the packaging RNA of phi29 bacteriophage. The resulting RNA nanostructures have been thoroughly characterized by gel electrophoresis, cryogenic electron microscopy imaging and dynamic light scattering.

Date: 2014
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DOI: 10.1038/ncomms4890

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