Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip

Ricardo Jiménez-Martínez, Daniel J. Kennedy, Michael Rosenbluh, Elizabeth A. Donley, Svenja Knappe, Scott J. Seltzer, Hattie L. Ring, Vikram S. Bajaj () and John Kitching ()
Additional contact information
Ricardo Jiménez-Martínez: National Institute of Standards and Technology
Daniel J. Kennedy: Lawrence Berkeley National Laboratory
Michael Rosenbluh: The Jack and Pearl Resnick Institute for Advanced Technology, Bar-Ilan University
Elizabeth A. Donley: National Institute of Standards and Technology
Svenja Knappe: National Institute of Standards and Technology
Scott J. Seltzer: Lawrence Berkeley National Laboratory
Hattie L. Ring: Lawrence Berkeley National Laboratory
Vikram S. Bajaj: Lawrence Berkeley National Laboratory
John Kitching: National Institute of Standards and Technology

Nature Communications, 2014, vol. 5, issue 1, 1-6

Abstract: Abstract Optically hyperpolarized 129Xe gas has become a powerful contrast agent in nuclear magnetic resonance (NMR) spectroscopy and imaging, with applications ranging from studies of the human lung to the targeted detection of biomolecules. Equally attractive is its potential use to enhance the sensitivity of microfluidic NMR experiments, in which small sample volumes yield poor sensitivity. Unfortunately, most 129Xe polarization systems are large and non-portable. Here we present a microfabricated chip that optically polarizes 129Xe gas. We have achieved 129Xe polarizations >0.5% at flow rates of several microlitres per second, compatible with typical microfluidic applications. We employ in situ optical magnetometry to sensitively detect and characterize the 129Xe polarization at magnetic fields of 1 μT. We construct the device using standard microfabrication techniques, which will facilitate its integration with existing microfluidic platforms. This device may enable the implementation of highly sensitive 129Xe NMR in compact, low-cost, portable devices.

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms4908 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4908

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms4908

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().