Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

Falguni Pati, Jinah Jang, Dong-Heon Ha, Sung Won Kim, Jong-Won Rhie, Jin-Hyung Shim, Deok-Ho Kim and Dong-Woo Cho ()
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Falguni Pati: Pohang University of Science and Technology (POSTECH)
Jinah Jang: Pohang University of Science and Technology (POSTECH)
Dong-Heon Ha: Pohang University of Science and Technology (POSTECH)
Sung Won Kim: College of Medicine, The Catholic University of Korea
Jong-Won Rhie: College of Medicine, The Catholic University of Korea
Jin-Hyung Shim: Korea Polytechnic University
Deok-Ho Kim: University of Washington
Dong-Woo Cho: Pohang University of Science and Technology (POSTECH)

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract The ability to print and pattern all the components that make up a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues is an exciting prospect of bioprinting. However, the majority of the matrix materials used so far for bioprinting cannot represent the complexity of natural extracellular matrix (ECM) and thus are unable to reconstitute the intrinsic cellular morphologies and functions. Here, we develop a method for the bioprinting of cell-laden constructs with novel decellularized extracellular matrix (dECM) bioink capable of providing an optimized microenvironment conducive to the growth of three-dimensional structured tissue. We show the versatility and flexibility of the developed bioprinting process using tissue-specific dECM bioinks, including adipose, cartilage and heart tissues, capable of providing crucial cues for cells engraftment, survival and long-term function. We achieve high cell viability and functionality of the printed dECM structures using our bioprinting method.

Date: 2014
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DOI: 10.1038/ncomms4935

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