Dynamic haematopoietic cell contribution to the developing and adult epicardium

Gemma M. Balmer, Sveva Bollini, Karina N. Dubé, Juan Pedro Martinez-Barbera, Owen Williams and Paul R. Riley ()
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Gemma M. Balmer: Molecular Medicine Unit, UCL-Institute of Child Health
Sveva Bollini: Regenerative Medicine Laboratory, University of Genoa & IRCCS AOU San Martino-IST, Largo Rosanna Benzi
Karina N. Dubé: Molecular Medicine Unit, UCL-Institute of Child Health
Juan Pedro Martinez-Barbera: Neural Development Unit, UCL-Institute of Child Health
Owen Williams: Molecular Haematology and Cancer Biology Unit, UCL-Institute of Child Health
Paul R. Riley: Anatomy and Genetics, University of Oxford

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract The epicardium is a cellular source with the potential to reconstitute lost cardiovascular tissue following myocardial infarction. Here we show that the adult epicardium contains a population of CD45+ haematopoietic cells (HCs), which are located proximal to coronary vessels and encased by extracellular matrix (ECM). This complex tertiary structure is established during the regenerative window between post-natal days 1 and 7. We show that these HCs proliferate within the first 24 h and are released between days 2 and 7 after myocardial infarction. The ECM subsequently reforms to encapsulate HCs after 21 days. Vav1-tdTomato labelling reveals an integral contribution of CD45+ HCs to the developing epicardium, which is not derived from the proepicardial organ. Transplantation experiments with either whole bone marrow or a Vav1+ subpopulation of cells confirm a contribution of HCs to the intact adult epicardium, which is elevated during the first 24 weeks of adult life but depleted in aged mice.

Date: 2014
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DOI: 10.1038/ncomms5054

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