Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes

Konstantin A. Tsetsarkin, Rubing Chen, Ruimei Yun, Shannan L. Rossi, Kenneth S. Plante, Mathilde Guerbois, Naomi Forrester, Guey Chuen Perng, Easwaran Sreekumar, Grace Leal, Jing Huang, Suchetana Mukhopadhyay and Scott C. Weaver ()
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Konstantin A. Tsetsarkin: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Rubing Chen: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Ruimei Yun: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Shannan L. Rossi: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Kenneth S. Plante: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Mathilde Guerbois: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Naomi Forrester: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Guey Chuen Perng: Emory Vaccine Center, Emory University School of Medicine
Easwaran Sreekumar: Viral Disease Biology Program, Rajiv Gandhi Centre for Biotechnology (RGCB)
Grace Leal: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Jing Huang: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch
Suchetana Mukhopadhyay: Indiana University
Scott C. Weaver: Center for Tropical Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch

Nature Communications, 2014, vol. 5, issue 1, 1-14

Abstract: Abstract Host species-specific fitness landscapes largely determine the outcome of host switching during pathogen emergence. Using chikungunya virus (CHIKV) to study adaptation to a mosquito vector, we evaluated mutations associated with recently evolved sub-lineages. Multiple Aedes albopictus-adaptive fitness peaks became available after CHIKV acquired an initial adaptive (E1-A226V) substitution, permitting rapid lineage diversification observed in nature. All second-step mutations involved replacements by glutamine or glutamic acid of E2 glycoprotein amino acids in the acid-sensitive region, providing a framework to anticipate additional A. albopictus-adaptive mutations. The combination of second-step adaptive mutations into a single, ‘super-adaptive’ fitness peak also predicted the future emergence of CHIKV strains with even greater transmission efficiency in some current regions of endemic circulation, followed by their likely global spread.

Date: 2014
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DOI: 10.1038/ncomms5084

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