An artificial primitive mimic of the Gramicidin-A channel

Mihail Barboiu (), Yann Le Duc, Arnaud Gilles, Pierre-André Cazade, Mathieu Michau, Yves Marie Legrand, Arie van der Lee, Benoît Coasne, Paria Parvizi, Joshua Post and Thomas Fyles
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Mihail Barboiu: Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM-UMII- UMR-CNRS5635, Place Eugène Bataillon CC047
Yann Le Duc: Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM-UMII- UMR-CNRS5635, Place Eugène Bataillon CC047
Arnaud Gilles: Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM-UMII- UMR-CNRS5635, Place Eugène Bataillon CC047
Pierre-André Cazade: Institut Charles Gerhardt Montpellier (ICGM), UMR 5253 CNRS/ENSCM/UMII, 8 rue de l’Ecole Normale
Mathieu Michau: Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM-UMII- UMR-CNRS5635, Place Eugène Bataillon CC047
Yves Marie Legrand: Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM-UMII- UMR-CNRS5635, Place Eugène Bataillon CC047
Arie van der Lee: Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM-UMII- UMR-CNRS5635, Place Eugène Bataillon CC047
Benoît Coasne: Institut Charles Gerhardt Montpellier (ICGM), UMR 5253 CNRS/ENSCM/UMII, 8 rue de l’Ecole Normale
Paria Parvizi: University of Victoria
Joshua Post: University of Victoria
Thomas Fyles: University of Victoria

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or ‘T-channel’ forming compound (TCT), having similar constitutional functions as the natural gAs. As in gA channels, the carbonyl moieties of the TCT, which point toward the T-channel core and surround the transport direction, are solvated by water. The net-dipolar alignment of water molecules along the chiral pore surfaces influences the conduction of protons/ions, envisioned to diffuse along dipolar hydrophilic pathways. Theoretical simulations and experimental assays reveal that the conduction through the T-channel, similar to that in gA, presents proton/water conduction, cation/anion selectivity and large open channel-conductance states. T-channels—associating supramolecular chirality with dipolar water alignment—represent an artificial primitive mimic of gA.

Date: 2014
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DOI: 10.1038/ncomms5142

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