CHOLINE TRANSPORTER-LIKE1 is required for sieve plate development to mediate long-distance cell-to-cell communication

Jan Dettmer, Robertas Ursache, Ana Campilho, Shunsuke Miyashima, Ilya Belevich, Seana O’Regan, Daniel Leroy Mullendore, Shri Ram Yadav, Christa Lanz, Luca Beverina, Antonio Papagni, Korbinian Schneeberger, Detlef Weigel, York-Dieter Stierhof, Thomas Moritz, Michael Knoblauch, Eija Jokitalo and Ykä Helariutta ()
Additional contact information
Jan Dettmer: University of Erlangen-Nuremberg
Robertas Ursache: Institute of Biotechnology, University of Helsinki
Ana Campilho: Institute for Molecular and Cell Biology (IBMC), University of Porto
Shunsuke Miyashima: Institute of Biotechnology, University of Helsinki
Ilya Belevich: Institute of Biotechnology, University of Helsinki
Seana O’Regan: Neurophotonics Laboratory, CNRS/Université Paris Descartes, 45, rue des Saints-Pères
Daniel Leroy Mullendore: School of Biological Sciences, Washington State University
Shri Ram Yadav: Institute of Biotechnology, University of Helsinki
Christa Lanz: Max Planck Institute for Developmental Biology
Luca Beverina: University of Milano-Bicocca, Via R. Cozzi 55
Antonio Papagni: University of Milano-Bicocca, Via R. Cozzi 55
Korbinian Schneeberger: Max Planck Institute for Plant Breeding Research
Detlef Weigel: Max Planck Institute for Developmental Biology
York-Dieter Stierhof: ZMBP, Mikroskopie, Universität Tübingen, Auf der Morgenstelle 5
Thomas Moritz: Umeå Plant Science Center, Swedish University of Agricultural Sciences
Michael Knoblauch: School of Biological Sciences, Washington State University
Eija Jokitalo: Institute of Biotechnology, University of Helsinki
Ykä Helariutta: Institute of Biotechnology, University of Helsinki

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract Phloem, a plant tissue responsible for long-distance molecular transport, harbours specific junctions, sieve areas, between the conducting cells. To date, little is known about the molecular framework related to the biogenesis of these sieve areas. Here we identify mutations at the CHER1/AtCTL1 locus of Arabidopsis thaliana. The mutations cause several phenotypic abnormalities, including reduced pore density and altered pore structure in the sieve areas associated with impaired phloem function. CHER1 encodes a member of a poorly characterized choline transporter-like protein family in plants and animals. We show that CHER1 facilitates choline transport, localizes to the trans-Golgi network, and during cytokinesis is associated with the phragmoplast. Consistent with its function in the elaboration of the sieve areas, CHER1 has a sustained, polar localization in the forming sieve plates. Our results indicate that the regulation of choline levels is crucial for phloem development and conductivity in plants.

Date: 2014
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DOI: 10.1038/ncomms5276

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