Sequencing-based approach identified three new susceptibility loci for psoriasis

Yujun Sheng, Xin Jin, Jinhua Xu, Jinping Gao, Xiaoqing Du, Dawei Duan, Bing Li, Jinhua Zhao, Wenying Zhan, Huayang Tang, Xianfa Tang, Yang Li, Hui Cheng, Xianbo Zuo, Junpu Mei, Fusheng Zhou, Bo Liang, Gang Chen, Changbing Shen, Hongzhou Cui, Xiaoguang Zhang, Change Zhang, Wenjun Wang, Xiaodong Zheng, Xing Fan, Zaixing Wang, Fengli Xiao, Yong Cui, Yingrui Li, Jun Wang, Sen Yang, Lei Xu (), Liangdan Sun () and Xuejun Zhang ()
Additional contact information
Yujun Sheng: No. 2 Hospital, Anhui Medical University
Xin Jin: BGI-Shenzhen
Jinhua Xu: Huashan Hospital of Fudan University
Jinping Gao: No. 1 Hospital, Anhui Medical University
Xiaoqing Du: No. 1 Hospital, Anhui Medical University
Dawei Duan: No. 1 Hospital, Anhui Medical University
Bing Li: No. 1 Hospital, Anhui Medical University
Jinhua Zhao: No. 1 Hospital, Anhui Medical University
Wenying Zhan: No. 1 Hospital, Anhui Medical University
Huayang Tang: No. 1 Hospital, Anhui Medical University
Xianfa Tang: No. 1 Hospital, Anhui Medical University
Yang Li: No. 1 Hospital, Anhui Medical University
Hui Cheng: No. 1 Hospital, Anhui Medical University
Xianbo Zuo: No. 1 Hospital, Anhui Medical University
Junpu Mei: BGI-Shenzhen
Fusheng Zhou: No. 1 Hospital, Anhui Medical University
Bo Liang: No. 1 Hospital, Anhui Medical University
Gang Chen: No. 1 Hospital, Anhui Medical University
Changbing Shen: No. 1 Hospital, Anhui Medical University
Hongzhou Cui: No. 1 Hospital, Anhui Medical University
Xiaoguang Zhang: No. 1 Hospital, Anhui Medical University
Change Zhang: No. 1 Hospital, Anhui Medical University
Wenjun Wang: No. 1 Hospital, Anhui Medical University
Xiaodong Zheng: No. 1 Hospital, Anhui Medical University
Xing Fan: No. 1 Hospital, Anhui Medical University
Zaixing Wang: No. 1 Hospital, Anhui Medical University
Fengli Xiao: No. 1 Hospital, Anhui Medical University
Yong Cui: No. 1 Hospital, Anhui Medical University
Yingrui Li: BGI-Shenzhen
Jun Wang: BGI-Shenzhen
Sen Yang: No. 1 Hospital, Anhui Medical University
Lei Xu: Rm1028 Ho Sin-Hang Engineering Building, The Chinese University of Hong Kong, Shatin, NT
Liangdan Sun: No. 1 Hospital, Anhui Medical University
Xuejun Zhang: No. 2 Hospital, Anhui Medical University

Nature Communications, 2014, vol. 5, issue 1, 1-6

Abstract: Abstract In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10−20≤P≤2.41 × 10−7) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10−8), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10−8) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10−8). Two suggestive loci, 3p21.31 and 17q25, are also identified with P

Date: 2014
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DOI: 10.1038/ncomms5331

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