The Opisthorchis viverrini genome provides insights into life in the bile duct

Neil D. Young, Niranjan Nagarajan, Suling Joyce Lin, Pasi K. Korhonen, Aaron R. Jex, Ross S. Hall, Helena Safavi-Hemami, Worasak Kaewkong, Denis Bertrand, Song Gao, Qihui Seet, Sopit Wongkham, Bin Tean Teh, Chaisiri Wongkham, Pewpan Maleewong Intapan, Wanchai Maleewong, Xinhua Yang, Min Hu, Zuo Wang, Andreas Hofmann, Paul W. Sternberg, Patrick Tan (), Jun Wang () and Robin B. Gasser ()
Additional contact information
Neil D. Young: Faculty of Veterinary Science, The University of Melbourne, Melbourne
Niranjan Nagarajan: Genome Institute of Singapore
Suling Joyce Lin: Genome Institute of Singapore
Pasi K. Korhonen: Faculty of Veterinary Science, The University of Melbourne, Melbourne
Aaron R. Jex: Faculty of Veterinary Science, The University of Melbourne, Melbourne
Ross S. Hall: Faculty of Veterinary Science, The University of Melbourne, Melbourne
Helena Safavi-Hemami: University of Utah
Worasak Kaewkong: Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University
Denis Bertrand: Genome Institute of Singapore
Song Gao: NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore
Qihui Seet: Genome Institute of Singapore
Sopit Wongkham: Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University
Bin Tean Teh: Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School
Chaisiri Wongkham: Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University
Pewpan Maleewong Intapan: Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University
Wanchai Maleewong: Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University
Andreas Hofmann: Faculty of Veterinary Science, The University of Melbourne, Melbourne
Paul W. Sternberg: HHMI, California Institute of Technology
Patrick Tan: Genome Institute of Singapore
Jun Wang: University of Copenhagen
Robin B. Gasser: Faculty of Veterinary Science, The University of Melbourne, Melbourne

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.

Date: 2014
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DOI: 10.1038/ncomms5378

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