Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

Sandra Hanks, Elizabeth R. Perdeaux, Sheila Seal, Elise Ruark, Shazia S. Mahamdallie, Anne Murray, Emma Ramsay, Silvana Del Vecchio Duarte, Anna Zachariou, Bianca de Souza, Margaret Warren-Perry, Anna Elliott, Alan Davidson, Helen Price, Charles Stiller, Kathy Pritchard-Jones and Nazneen Rahman ()
Additional contact information
Sandra Hanks: Institute of Cancer Research
Elizabeth R. Perdeaux: Institute of Cancer Research
Sheila Seal: Institute of Cancer Research
Elise Ruark: Institute of Cancer Research
Shazia S. Mahamdallie: Institute of Cancer Research
Anne Murray: Institute of Cancer Research
Emma Ramsay: Institute of Cancer Research
Silvana Del Vecchio Duarte: Institute of Cancer Research
Anna Zachariou: Institute of Cancer Research
Bianca de Souza: Institute of Cancer Research
Margaret Warren-Perry: Institute of Cancer Research
Anna Elliott: Institute of Cancer Research
Alan Davidson: Red Cross Children’s Hospital, University of Cape Town
Helen Price: Great Western Hospital
Charles Stiller: Childhood Cancer Research Group, University of Oxford
Kathy Pritchard-Jones: Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London
Nazneen Rahman: Institute of Cancer Research

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 Wilms tumour families, through exome and Sanger sequencing. By contrast, no similar mutations are present in 1,000 population controls (P

Date: 2014
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DOI: 10.1038/ncomms5398

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