LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria

Xiaomin Su, Siping Min, Shuisong Cao, Hui Yan, Yining Zhao, Hui Li, Limin Chai, Shiyue Mei, Jia Yang, Yuan Zhang, Zhujun Zhang, Feifei Liu, Wei Sun, Yongzhe Che () and Rongcun Yang ()
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Xiaomin Su: Nankai University School of Medicine, Nankai University
Siping Min: Nankai University School of Medicine, Nankai University
Shuisong Cao: Nankai University School of Medicine, Nankai University
Hui Yan: Nankai University School of Medicine, Nankai University
Yining Zhao: Nankai University School of Medicine, Nankai University
Hui Li: Nankai University School of Medicine, Nankai University
Limin Chai: Nankai University School of Medicine, Nankai University
Shiyue Mei: Nankai University School of Medicine, Nankai University
Jia Yang: Nankai University School of Medicine, Nankai University
Yuan Zhang: Nankai University School of Medicine, Nankai University
Zhujun Zhang: Nankai University School of Medicine, Nankai University
Feifei Liu: Nankai University School of Medicine, Nankai University
Wei Sun: Nankai University School of Medicine, Nankai University
Yongzhe Che: Nankai University School of Medicine, Nankai University
Rongcun Yang: Nankai University School of Medicine, Nankai University

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract The innate immune-dependent bactericidal effects are critical for preventing microbial colonization in the urinary system. However, the mechanisms involved in establishing innate immune responses in kidney are not completely understood. Here we describe the role of a novel member of the LRR (leucine-rich repeat) class of transmembrane proteins, LRRC19 (LRR-containing 19) in eliminating uropathogenic bacteria. LRRC19 is predominantly expressed in human and mouse kidney tubular epithelial cells and LRRC19-deficient mice are more susceptible to uropathogenic Escherichia coli (UPEC) infection than wild-type or TLR4 knockout mice. Recognition of UPEC by LRRC19 induces the production of cytokines, chemokines and antimicrobial substances through TRAF2- and TRAF6-mediated NF-κB and MAPK signalling pathways. Thus, LRRC19 may be a critical pathogen-recognition receptor in kidney mediating the elimination of UPEC infection.

Date: 2014
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DOI: 10.1038/ncomms5434

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