Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

Bo Zhu, Shyh-Chyang Luo, Haichao Zhao, Hsing-An Lin, Jun Sekine, Aiko Nakao, Chi Chen, Yoshiro Yamashita and Hsiao-hua Yu ()
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Bo Zhu: Responsive Organic Materials Laboratory, RIKEN
Shyh-Chyang Luo: Responsive Organic Materials Laboratory, RIKEN
Haichao Zhao: Responsive Organic Materials Laboratory, RIKEN
Hsing-An Lin: Responsive Organic Materials Laboratory, RIKEN
Jun Sekine: Responsive Organic Materials Laboratory, RIKEN
Aiko Nakao: RNC Nuclear Spectroscopy Laboratory, RIKEN, Wako
Chi Chen: Research Center for Applied Sciences, Academia Sinica, Nankang
Yoshiro Yamashita: Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology
Hsiao-hua Yu: Responsive Organic Materials Laboratory, RIKEN

Nature Communications, 2014, vol. 5, issue 1, 1-9

Abstract: Abstract Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, thereby reducing the lifetime of the device. Ideally, an electrode material capable of electrically interfacing with neurons selectively and efficiently would be integrated without being recognized by the immune system and minimize its response. Here we develop a cell membrane-mimicking conducting polymer possessing several attractive features. This polymer displays high resistance towards nonspecific enzyme/cell binding and recognizes targeted cells specifically to allow intimate electrical communication over long periods of time. Its low electrical impedance relays electrical signals efficiently. This material is capable to integrate biochemical and electrical stimulation to promote neural cellular behaviour. Neurite outgrowth is enhanced greatly on this new conducting polymer; in addition, electrically stimulated secretion of proteins from primary Schwann cells can also occur on it.

Date: 2014
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DOI: 10.1038/ncomms5523

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