Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA

Haruko Ota, Takao Hikita, Masato Sawada, Tomoki Nishioka, Mami Matsumoto, Masayuki Komura, Akihisa Ohno, Yukiyo Kamiya, Takuya Miyamoto, Naoya Asai, Atsushi Enomoto, Masahide Takahashi, Kozo Kaibuchi, Kazuya Sobue and Kazunobu Sawamoto ()
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Haruko Ota: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Takao Hikita: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Masato Sawada: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Tomoki Nishioka: Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku
Mami Matsumoto: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Masayuki Komura: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Akihisa Ohno: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Yukiyo Kamiya: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Takuya Miyamoto: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Naoya Asai: Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku
Atsushi Enomoto: Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku
Masahide Takahashi: Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku
Kozo Kaibuchi: Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku
Kazuya Sobue: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku
Kazunobu Sawamoto: Graduate School of Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Throughout life, new neurons generated in the ventricular–subventricular zone take the long journey to the olfactory bulb. The intracellular mechanisms that precisely control the neurons’ migration speed, enabling their well-organized movement, remain unclear. Rho signalling is known to affect the morphology and movement of various cell types, including neurons. Here we identify Gem-interacting protein (Gmip), a RhoA-specific GTPase-activating protein, as a key factor in saltatory neuronal migration. RhoA is activated at the proximal leading process of migrating neurons, where Gmip is also localized and negatively regulates RhoA. Gmip controls the saltatory movement of neurons that regulate their migration speed and ‘stop’ positions in the olfactory bulb, thereby altering the neural circuitry. This study demonstrates that Gmip serves as a brake for the RhoA-mediated movement of neuronal somata, and highlights the significance of speed control in the well-organized neuronal migration and the maintenance of neuronal circuits in the postnatal brain.

Date: 2014
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DOI: 10.1038/ncomms5532

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