Jarid2 is induced by TCR signalling and controls iNKT cell maturation

Renata M. Pereira, Gustavo J. Martinez, Isaac Engel, Fernando Cruz-Guilloty, Bianca A. Barboza, Ageliki Tsagaratou, Chan-Wang J. Lio, Leslie J. Berg, Youngsook Lee, Mitchell Kronenberg, Hozefa S. Bandukwala () and Anjana Rao ()
Additional contact information
Renata M. Pereira: La Jolla Institute for Allergy and Immunology
Gustavo J. Martinez: La Jolla Institute for Allergy and Immunology
Isaac Engel: La Jolla Institute for Allergy and Immunology
Fernando Cruz-Guilloty: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Bianca A. Barboza: La Jolla Institute for Allergy and Immunology
Ageliki Tsagaratou: La Jolla Institute for Allergy and Immunology
Chan-Wang J. Lio: La Jolla Institute for Allergy and Immunology
Leslie J. Berg: University of Massachusetts Medical School
Youngsook Lee: School of Medicine and Public Health, University of Wisconsin
Mitchell Kronenberg: La Jolla Institute for Allergy and Immunology
Hozefa S. Bandukwala: La Jolla Institute for Allergy and Immunology
Anjana Rao: La Jolla Institute for Allergy and Immunology

Nature Communications, 2014, vol. 5, issue 1, 1-14

Abstract: Abstract Jarid2 is a reported component of three lysine methyltransferase complexes, polycomb repressive complex 2 (PRC2) that methylates histone 3 lysine 27 (H3K27), and GLP-G9a and SETDB1 complexes that methylate H3K9. Here we show that Jarid2 is upregulated upon TCR stimulation and during positive selection in the thymus. Mice lacking Jarid2 in T cells display an increase in the frequency of IL-4-producing promyelocytic leukemia zinc finger (PLZF)hi immature invariant natural killer T (iNKT) cells and innate-like CD8+ cells; Itk-deficient mice, which have a similar increase of innate-like CD8+ cells, show blunted upregulation of Jarid2 during positive selection. Jarid2 binds to the Zbtb16 locus, which encodes PLZF, and thymocytes lacking Jarid2 show increased PLZF and decreased H3K9me3 levels. Jarid2-deficient iNKT cells perturb Th17 differentiation, leading to reduced Th17-driven autoimmune pathology. Our results establish Jarid2 as a novel player in iNKT cell maturation that regulates PLZF expression by modulating H3K9 methylation.

Date: 2014
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DOI: 10.1038/ncomms5540

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