Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model

N. Lozovaya (), S. Gataullina, T. Tsintsadze, V. Tsintsadze, E. Pallesi-Pocachard, M. Minlebaev, N. A. Goriounova, E. Buhler, F. Watrin, S. Shityakov, A. J. Becker, A. Bordey, M. Milh, D. Scavarda, C. Bulteau, G. Dorfmuller, O. Delalande, A. Represa, C. Cardoso, O. Dulac, Y. Ben-Ari and N. Burnashev ()
Additional contact information
N. Lozovaya: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
S. Gataullina: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
T. Tsintsadze: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
V. Tsintsadze: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
E. Pallesi-Pocachard: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
M. Minlebaev: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
N. A. Goriounova: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
E. Buhler: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
F. Watrin: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
S. Shityakov: University of Würzburg
A. J. Becker: University of Bonn Medical Center
A. Bordey: Neurosurgery, Yale University School of Medicine
M. Milh: APHM, CHU Timone
D. Scavarda: APHM, CHU Timone
C. Bulteau: INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
G. Dorfmuller: INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
O. Delalande: Foundation Rothschild
A. Represa: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
C. Cardoso: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
O. Dulac: INSERM U1129; University Paris Descartes, CEA, Gif sur Yvette
Y. Ben-Ari: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163
N. Burnashev: INSERM U901, INMED, Parc Scientifique et Technologique de Luminy 163

Nature Communications, 2014, vol. 5, issue 1, 1-15

Abstract: Abstract Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless heterozygote Tsc1+/− mice show functional upregulation of cortical GluN2C-containing N-methyl-D-aspartate receptors (NMDARs) in an mTOR-dependent manner and exhibit recurrent, unprovoked seizures during early postnatal life (

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms5563 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5563

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms5563

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().