Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity

Thomas Vogl (), Michel Eisenblätter, Tom Völler, Stefanie Zenker, Sven Hermann, Peter van Lent, Andreas Faust, Christiane Geyer, Beatrix Petersen, Kirsten Roebrock, Michael Schäfers, Christoph Bremer and Johannes Roth
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Thomas Vogl: Institute of Immunology, University of Münster
Michel Eisenblätter: King’s College London
Tom Völler: Institute of Immunology, University of Münster
Stefanie Zenker: Institute of Immunology, University of Münster
Sven Hermann: Interdisciplinary Centre for Clinical Research, University of Münster
Peter van Lent: Radboud University Medical Centre
Andreas Faust: European Institute for Molecular Imaging, University of Münster
Christiane Geyer: Interdisciplinary Centre for Clinical Research, University of Münster
Beatrix Petersen: Institute of Immunology, University of Münster
Kirsten Roebrock: Institute of Immunology, University of Münster
Michael Schäfers: European Institute for Molecular Imaging, University of Münster
Christoph Bremer: Interdisciplinary Centre for Clinical Research, University of Münster
Johannes Roth: Institute of Immunology, University of Münster

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Inflammation has a key role in the pathogenesis of various human diseases. The early detection, localization and monitoring of inflammation are crucial for tailoring individual therapies. However, reliable biomarkers to detect local inflammatory activities and to predict disease outcome are still missing. Alarmins, which are locally released during cellular stress, are early amplifiers of inflammation. Here, using optical molecular imaging, we demonstrate that the alarmin S100A8/S100A9 serves as a sensitive local and systemic marker for the detection of even sub-clinical disease activity in inflammatory and immunological processes like irritative and allergic contact dermatitis. In a model of collagen-induced arthritis, we use S100A8/S100A9 imaging to predict the development of disease activity. Furthermore, S100A8/S100A9 can act as a very early and sensitive biomarker in experimental leishmaniasis for phagocyte activation linked to an effective Th1-response. In conclusion, the alarmin S100A8/S100A9 is a valuable and sensitive molecular target for novel imaging approaches to monitor clinically relevant inflammatory disorders on a molecular level.

Date: 2014
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DOI: 10.1038/ncomms5593

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