Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Hansong Wang, Terrilea Burnett, Suminori Kono, Christopher A. Haiman, Motoki Iwasaki, Lynne R. Wilkens, Lenora W. M. Loo, David Van Den Berg, Laurence N. Kolonel, Brian E. Henderson, Temitope O. Keku, Robert S. Sandler, Lisa B. Signorello, William J. Blot, Polly A. Newcomb, Mala Pande, Christopher I. Amos, Dee W. West, Stéphane Bézieau, Sonja I. Berndt, Brent W. Zanke, Li Hsu, Noralane M. Lindor, Robert W. Haile, John L. Hopper, Mark A. Jenkins, Steven Gallinger, Graham Casey, Stephanie L. Stenzel, Fredrick R. Schumacher, Ulrike Peters, Stephen B. Gruber, Shoichiro Tsugane, Daniel O. Stram and Loïc Le Marchand ()
Additional contact information
Hansong Wang: Epidemiology Program, University of Hawaii Cancer Center
Terrilea Burnett: Epidemiology Program, University of Hawaii Cancer Center
Suminori Kono: Graduate School of Medical Sciences, Kyushu University
Christopher A. Haiman: Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
Motoki Iwasaki: Research Center for Cancer Prevention and Screening, National Cancer Center
Lynne R. Wilkens: Epidemiology Program, University of Hawaii Cancer Center
Lenora W. M. Loo: Epidemiology Program, University of Hawaii Cancer Center
David Van Den Berg: Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
Laurence N. Kolonel: Epidemiology Program, University of Hawaii Cancer Center
Brian E. Henderson: Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
Temitope O. Keku: Center for Gastrointestinal Biology and Disease, University of North Carolina
Robert S. Sandler: Center for Gastrointestinal Biology and Disease, University of North Carolina
Lisa B. Signorello: Harvard School of Public Health, Harvard Medical School
William J. Blot: Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center
Polly A. Newcomb: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Mala Pande: the University of Texas MD Anderson Cancer Center
Christopher I. Amos: Geisel School of Medicine, Dartmouth College
Dee W. West: Cancer Prevention Institute of California
Stéphane Bézieau: Service de Génétique Médicale, CHU Nantes
Sonja I. Berndt: National Cancer Institute, National Institutes of Health
Brent W. Zanke: Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute
Li Hsu: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Steven Gallinger: Cancer Care Ontario
Graham Casey: Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
Stephanie L. Stenzel: Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
Ulrike Peters: Cancer Prevention Program, Fred Hutchinson Cancer Research Center
Shoichiro Tsugane: Research Center for Cancer Prevention and Screening, National Cancer Center
Daniel O. Stram: Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P

Date: 2014
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DOI: 10.1038/ncomms5613

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