Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women

Kexin Chen (), Hongxia Ma, Lian Li, Rongyu Zang, Cheng Wang, Fengju Song, Tingyan Shi, Dianke Yu, Ming Yang, Wenqiong Xue, Juncheng Dai, Shuang Li, Hong Zheng, Chen Wu, Ying Zhang, Xiaohua Wu, Dake Li, Fengxia Xue, Haixin Li, Zhi Jiang, Jibin Liu, Yuexin Liu, Pei Li, Wen Tan, Jing Han, Jiang Jie, Quan Hao, Zhibin Hu, Dongxin Lin, Ding Ma (), Weihua Jia (), Hongbing Shen () and Qingyi Wei ()
Additional contact information
Kexin Chen: National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital
Hongxia Ma: State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University
Lian Li: National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital
Rongyu Zang: Fudan University Shanghai Cancer Center
Cheng Wang: State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University
Fengju Song: National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital
Tingyan Shi: Fudan University Shanghai Cancer Center
Dianke Yu: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Ming Yang: College of Life Science and Technology, Beijing University of Chemical Technology
Wenqiong Xue: State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University
Juncheng Dai: State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University
Shuang Li: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hong Zheng: National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital
Chen Wu: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Ying Zhang: State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University
Xiaohua Wu: Fudan University Shanghai Cancer Center
Dake Li: Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM
Fengxia Xue: Tianjin Medical University General Hospital
Haixin Li: National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital
Zhi Jiang: Jiangsu Cancer Hospital, Nanjing Medical University
Jibin Liu: Nantong Tumor Hospital
Yuexin Liu: The University of Texas MD Anderson Cancer Center
Pei Li: National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital
Wen Tan: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Jing Han: State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University
Jiang Jie: State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University
Quan Hao: Tianjin Medical University Cancer Institute and Hospital
Zhibin Hu: State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University
Dongxin Lin: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Ding Ma: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Weihua Jia: State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University
Hongbing Shen: State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University
Qingyi Wei: Cancer Institute, Fudan University Shanghai Cancer Center

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (Pmeta

Date: 2014
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DOI: 10.1038/ncomms5682

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