Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis

Tingli Liu, Tianqiao Song, Xiong Zhang, Hongbo Yuan, Liming Su, Wanlin Li, Jing Xu, Shiheng Liu, Linlin Chen, Tianzi Chen, Meixiang Zhang, Lichuan Gu, Baolong Zhang () and Daolong Dou ()
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Tingli Liu: Nanjing Agricultural University
Tianqiao Song: Nanjing Agricultural University
Xiong Zhang: Nanjing Agricultural University
Hongbo Yuan: Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences
Liming Su: Nanjing Agricultural University
Wanlin Li: Nanjing Agricultural University
Jing Xu: Nanjing Agricultural University
Shiheng Liu: State Key Laboratory of Microbial Technology, Shandong University
Linlin Chen: Nanjing Agricultural University
Tianzi Chen: Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences
Meixiang Zhang: Nanjing Agricultural University
Lichuan Gu: State Key Laboratory of Microbial Technology, Shandong University
Baolong Zhang: Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences
Daolong Dou: Nanjing Agricultural University

Nature Communications, 2014, vol. 5, issue 1, 1-10

Abstract: Abstract Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we show that Phytophthora sojae and Verticillium dahliae secrete isochorismatases (PsIsc1 and VdIsc1, respectively) that are required for full pathogenesis. PsIsc1 and VdIsc1 can suppress salicylate-mediated innate immunity in planta and hydrolyse isochorismate in vitro. A conserved triad of catalytic residues is essential for both functions. Thus, the two proteins are isochorismatase effectors that disrupt the plant salicylate metabolism pathway by suppressing its precursor. Furthermore, these proteins lack signal peptides, but exhibit characteristics that lead to unconventional secretion. Therefore, this secretion pathway is a novel mechanism for delivering effectors and might play an important role in host–pathogen interactions.

Date: 2014
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DOI: 10.1038/ncomms5686

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