A metabolic view on menopause and ageing

Kirsi Auro (), Anni Joensuu, Krista Fischer, Johannes Kettunen, Perttu Salo, Hannele Mattsson, Marjo Niironen, Jaakko Kaprio, Johan G. Eriksson, Terho Lehtimäki, Olli Raitakari, Antti Jula, Aila Tiitinen, Matti Jauhiainen, Pasi Soininen, Antti J. Kangas, Mika Kähönen, Aki S. Havulinna, Mika Ala-Korpela, Veikko Salomaa, Andres Metspalu and Markus Perola
Additional contact information
Kirsi Auro: Public Health Genomics Unit, National Institute for Health and Welfare
Anni Joensuu: Public Health Genomics Unit, National Institute for Health and Welfare
Krista Fischer: Estonian Genome Center, University of Tartu
Johannes Kettunen: Public Health Genomics Unit, National Institute for Health and Welfare
Perttu Salo: Public Health Genomics Unit, National Institute for Health and Welfare
Hannele Mattsson: Public Health Genomics Unit, National Institute for Health and Welfare
Marjo Niironen: Public Health Genomics Unit, National Institute for Health and Welfare
Jaakko Kaprio: Institute for Molecular Medicine (FIMM), University of Helsinki
Johan G. Eriksson: Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare
Terho Lehtimäki: Fimlab Laboratories, University of Tampere School of Medicine, Tampere University
Olli Raitakari: Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku
Antti Jula: Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare
Aila Tiitinen: Helsinki University Central Hospital and University of Helsinki
Matti Jauhiainen: Public Health Genomics Unit, National Institute for Health and Welfare
Pasi Soininen: Computational Medicine, Institute of Health Sciences, University of Oulu
Antti J. Kangas: Computational Medicine, Institute of Health Sciences, University of Oulu
Mika Kähönen: Tampere University Hospital and University of Tampere School of Medicine, Tampere University
Aki S. Havulinna: Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare
Mika Ala-Korpela: Computational Medicine, Institute of Health Sciences, University of Oulu
Veikko Salomaa: Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare
Andres Metspalu: Estonian Genome Center, University of Tartu
Markus Perola: Public Health Genomics Unit, National Institute for Health and Welfare

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract The ageing of the global population calls for a better understanding of age-related metabolic consequences. Here we report the effects of age, sex and menopause on serum metabolites in 26,065 individuals of Northern European ancestry. Age-specific metabolic fingerprints differ significantly by gender and, in females, a substantial atherogenic shift overlapping the time of menopausal transition is observed. In meta-analysis of 10,083 women, menopause status associates with amino acids glutamine, tyrosine and isoleucine, along with serum cholesterol measures and atherogenic lipoproteins. Among 3,204 women aged 40–55 years, menopause status associates additionally with glycine and total, monounsaturated, and omega-7 and -9 fatty acids. Our findings suggest that, in addition to lipid alterations, menopause may contribute to future metabolic and cardiovascular risk via influencing amino-acid concentrations, adding to the growing evidence of the importance of amino acids in metabolic disease progression. These observations shed light on the metabolic consequences of ageing, gender and menopause at the population level.

Date: 2014
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DOI: 10.1038/ncomms5708

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