A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Yuanpei Li (), Tzu-yin Lin, Yan Luo, Qiangqiang Liu, Wenwu Xiao, Wenchang Guo, Diana Lac, Hongyong Zhang, Caihong Feng, Sebastian Wachsmann-Hogiu, Jeffrey H. Walton, Simon R. Cherry, Douglas J. Rowland, David Kukis, Chongxian Pan () and Kit S. Lam ()
Additional contact information
Yuanpei Li: UC Davis Comprehensive Cancer Center, University of California Davis
Tzu-yin Lin: University of California Davis
Yan Luo: UC Davis Comprehensive Cancer Center, University of California Davis
Qiangqiang Liu: UC Davis Comprehensive Cancer Center, University of California Davis
Wenwu Xiao: UC Davis Comprehensive Cancer Center, University of California Davis
Wenchang Guo: UC Davis Comprehensive Cancer Center, University of California Davis
Diana Lac: UC Davis Comprehensive Cancer Center, University of California Davis
Hongyong Zhang: University of California Davis
Caihong Feng: UC Davis Comprehensive Cancer Center, University of California Davis
Sebastian Wachsmann-Hogiu: NSF Center for Biophotonics Science and Technology, University of California Davis
Jeffrey H. Walton: UC Davis Comprehensive Cancer Center, University of California Davis
Simon R. Cherry: Center for Molecular and Genomic Imaging, University of California Davis
Douglas J. Rowland: Center for Molecular and Genomic Imaging, University of California Davis
David Kukis: Center for Molecular and Genomic Imaging, University of California Davis
Chongxian Pan: University of California Davis
Kit S. Lam: UC Davis Comprehensive Cancer Center, University of California Davis

Nature Communications, 2014, vol. 5, issue 1, 1-15

Abstract: Abstract Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart ‘all-in-one’ nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

Date: 2014
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DOI: 10.1038/ncomms5712

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