UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

Cristina Militti, Sylvain Maenner, Peter B. Becker and Fátima Gebauer ()
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Cristina Militti: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG)
Sylvain Maenner: Adolf-Butenandt-Institute and Center for Integrated Protein Science, Ludwig-Maximilians University
Peter B. Becker: Adolf-Butenandt-Institute and Center for Integrated Protein Science, Ludwig-Maximilians University
Fátima Gebauer: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG)

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.

Date: 2014
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DOI: 10.1038/ncomms5762

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