Scalable high-density peptide arrays for comprehensive health monitoring

Joseph Barten Legutki, Zhan-Gong Zhao, Matt Greving, Neal Woodbury, Stephen Albert Johnston and Phillip Stafford ()
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Joseph Barten Legutki: Center for Innovations in Medicine, Biodesign Institute, Arizona State University
Zhan-Gong Zhao: Center for Innovations in Medicine, Biodesign Institute, Arizona State University
Matt Greving: NextVal
Neal Woodbury: Center for Innovations in Medicine, Biodesign Institute, Arizona State University
Stephen Albert Johnston: Center for Innovations in Medicine, Biodesign Institute, Arizona State University
Phillip Stafford: Center for Innovations in Medicine, Biodesign Institute, Arizona State University

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract There is an increasing awareness that health care must move from post-symptomatic treatment to presymptomatic intervention. An ideal system would allow regular inexpensive monitoring of health status using circulating antibodies to report on health fluctuations. Recently, we demonstrated that peptide microarrays can do this through antibody signatures (immunosignatures). Unfortunately, printed microarrays are not scalable. Here we demonstrate a platform based on fabricating microarrays (~10 M peptides per slide, 330,000 peptides per assay) on silicon wafers using equipment common to semiconductor manufacturing. The potential of these microarrays for comprehensive health monitoring is verified through the simultaneous detection and classification of six different infectious diseases and six different cancers. Besides diagnostics, these high-density peptide chips have numerous other applications both in health care and elsewhere.

Date: 2014
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DOI: 10.1038/ncomms5785

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