Electrophoretic and field-effect graphene for all-electrical DNA array technology

Guangyu Xu, Jeffrey Abbott, Ling Qin, Kitty Y. M. Yeung, Yi Song, Hosang Yoon, Jing Kong and Donhee Ham ()
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Guangyu Xu: School of Engineering and Applied Sciences, Harvard University
Jeffrey Abbott: School of Engineering and Applied Sciences, Harvard University
Ling Qin: School of Engineering and Applied Sciences, Harvard University
Kitty Y. M. Yeung: School of Engineering and Applied Sciences, Harvard University
Yi Song: Massachusetts Institute of Technology
Hosang Yoon: School of Engineering and Applied Sciences, Harvard University
Jing Kong: Massachusetts Institute of Technology
Donhee Ham: School of Engineering and Applied Sciences, Harvard University

Nature Communications, 2014, vol. 5, issue 1, 1-9

Abstract: Abstract Field-effect transistor biomolecular sensors based on low-dimensional nanomaterials boast sensitivity, label-free operation and chip-scale construction. Chemical vapour deposition graphene is especially well suited for multiplexed electronic DNA array applications, since its large two-dimensional morphology readily lends itself to top-down fabrication of transistor arrays. Nonetheless, graphene field-effect transistor DNA sensors have been studied mainly at single-device level. Here we create, from chemical vapour deposition graphene, field-effect transistor arrays with two features representing steps towards multiplexed DNA arrays. First, a robust array yield—seven out of eight transistors—is achieved with a 100-fM sensitivity, on par with optical DNA microarrays and at least 10 times higher than prior chemical vapour deposition graphene transistor DNA sensors. Second, each graphene acts as an electrophoretic electrode for site-specific probe DNA immobilization, and performs subsequent site-specific detection of target DNA as a field-effect transistor. The use of graphene as both electrode and transistor suggests a path towards all-electrical multiplexed graphene DNA arrays.

Date: 2014
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DOI: 10.1038/ncomms5866

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