Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

Ke Cheng (), Deliang Shen, M. Taylor Hensley, Ryan Middleton, Baiming Sun, Weixin Liu, Geoffrey De Couto and Eduardo Marbán ()
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Ke Cheng: Cedars-Sinai Heart Institute
Deliang Shen: First Affiliated Hospital of Zhengzhou University
M. Taylor Hensley: Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, 1060 William Moore Drive, North Carolina State University
Ryan Middleton: Cedars-Sinai Heart Institute
Baiming Sun: Cedars-Sinai Heart Institute
Weixin Liu: Cedars-Sinai Heart Institute
Geoffrey De Couto: Cedars-Sinai Heart Institute
Eduardo Marbán: Cedars-Sinai Heart Institute

Nature Communications, 2014, vol. 5, issue 1, 1-9

Abstract: Abstract Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in vivo cell-mediated tissue repair, imaging and localized enrichment without cellular transplantation. Iron nanoparticles are conjugated with two types of antibodies (one against antigens on therapeutic cells and the other directed at injured cells) to produce magnetic bifunctional cell engager (MagBICE). The antibodies link the therapeutic cells to the injured cells, whereas the iron core of MagBICE enables physical enrichment and imaging. We treat acute myocardial infarction by targeting exogenous bone marrow-derived stem cells (expressing CD45) or endogenous CD34-positive cells to injured cardiomyocytes (expressing myosin light chain. Targeting can be further enhanced by magnetic attraction, leading to augmented functional benefits. MagBICE represents a generalizable platform technology for regenerative medicine.

Date: 2014
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DOI: 10.1038/ncomms5880

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