The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics

Xing-Jiang Yu, Zhaohong Yi, Zheng Gao, Dandan Qin, Yanhua Zhai, Xue Chen, Yingchun Ou-Yang, Zhen-Bo Wang, Ping Zheng, Min-Sheng Zhu, Haibin Wang, Qing-Yuan Sun, Jurrien Dean () and Lei Li ()
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Xing-Jiang Yu: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Zhaohong Yi: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Zheng Gao: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Dandan Qin: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Yanhua Zhai: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Xue Chen: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Yingchun Ou-Yang: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Zhen-Bo Wang: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Ping Zheng: State Key laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Min-Sheng Zhu: Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University
Haibin Wang: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Qing-Yuan Sun: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Jurrien Dean: Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health
Lei Li: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences

Nature Communications, 2014, vol. 5, issue 1, 1-12

Abstract: Abstract Maternal effect genes play critical roles in early embryogenesis of model organisms where they have been intensively investigated. However, their molecular function in mammals remains largely unknown. Recently, we identified a subcortical maternal complex (SCMC) that contains four proteins encoded by maternal effect genes (Mater, Filia, Floped and Tle6). Here we report that TLE6, similar to FLOPED and MATER, stabilizes the SCMC and is necessary for cleavage beyond the two-cell stage of development. We document that the SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division of mouse zygotes. We further demonstrate that the SCMC controls formation of the actin cytoskeleton specifically via Cofilin, a key regulator of F-actin assembly. Our results provide molecular insight into the physiological function of TLE6, its interaction with the SCMC and their roles in the symmetric division of the zygote in early mouse development.

Date: 2014
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DOI: 10.1038/ncomms5887

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