Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

Beben Benyamin (), Tonu Esko, Janina S. Ried, Aparna Radhakrishnan, Sita H. Vermeulen, Michela Traglia, Martin Gögele, Denise Anderson, Linda Broer, Clara Podmore, Jian’an Luan, Zoltan Kutalik, Serena Sanna, Peter van der Meer, Toshiko Tanaka, Fudi Wang, Harm-Jan Westra, Lude Franke, Evelin Mihailov, Lili Milani, Jonas Hälldin, Juliane Winkelmann, Thomas Meitinger, Joachim Thiery, Annette Peters, Melanie Waldenberger, Augusto Rendon, Jennifer Jolley, Jennifer Sambrook, Lambertus A. Kiemeney, Fred C. Sweep, Cinzia F. Sala, Christine Schwienbacher, Irene Pichler, Jennie Hui, Ayse Demirkan, Aaron Isaacs, Najaf Amin, Maristella Steri, Gérard Waeber, Niek Verweij, Joseph E. Powell, Dale R. Nyholt, Andrew C. Heath, Pamela A. F. Madden, Peter M. Visscher, Margaret J. Wright, Grant W. Montgomery, Nicholas G. Martin, Dena Hernandez, Stefania Bandinelli, Pim van der Harst, Manuela Uda, Peter Vollenweider, Robert A. Scott, Claudia Langenberg, Nicholas J. Wareham, Cornelia van Duijn, John Beilby, Peter P. Pramstaller, Andrew A. Hicks, Willem H. Ouwehand, Konrad Oexle, Christian Gieger, Andres Metspalu, Clara Camaschella, Daniela Toniolo, Dorine W. Swinkels and John B. Whitfield ()
Additional contact information
Beben Benyamin: The University of Queensland, Queensland Brain Institute
Tonu Esko: Estonian Genome Center, University of Tartu
Janina S. Ried: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstraße 1
Aparna Radhakrishnan: University of Cambridge
Sita H. Vermeulen: Radboud University Medical Centre
Michela Traglia: San Raffaele Scientific Institute
Martin Gögele: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC)
Denise Anderson: Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia
Linda Broer: Erasmus Medical Center
Clara Podmore: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus
Jian’an Luan: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus
Zoltan Kutalik: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
Serena Sanna: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato
Peter van der Meer: University of Groningen, University Medical Center Groningen
Toshiko Tanaka: Translational Gerontology Branch, National Institute on Aging
Fudi Wang: School of Public Health, Zhejiang University
Harm-Jan Westra: University Medical Center Groningen
Lude Franke: University Medical Center Groningen
Evelin Mihailov: Estonian Genome Center, University of Tartu
Lili Milani: Estonian Genome Center, University of Tartu
Jonas Hälldin: Estonian Genome Center, University of Tartu
Juliane Winkelmann: Stanford University
Thomas Meitinger: Institut für Humangenetik, Helmholtz Zentrum München
Joachim Thiery: Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig
Annette Peters: Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
Melanie Waldenberger: Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
Augusto Rendon: University of Cambridge
Jennifer Jolley: University of Cambridge
Jennifer Sambrook: University of Cambridge
Lambertus A. Kiemeney: Radboud University Medical Centre
Fred C. Sweep: Laboratory of Genetic, Endocrine and Metabolic Diseases (LGEM), Radboud University Medical Centre
Cinzia F. Sala: San Raffaele Scientific Institute
Christine Schwienbacher: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC)
Irene Pichler: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC)
Jennie Hui: PathWest Laboratory Medicine of WA
Ayse Demirkan: Erasmus Medical Center
Aaron Isaacs: Erasmus Medical Center
Najaf Amin: Erasmus Medical Center
Maristella Steri: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato
Gérard Waeber: Internal Medicine, CHUV, University of Lausanne
Niek Verweij: University of Groningen, University Medical Center Groningen
Joseph E. Powell: The University of Queensland, Queensland Brain Institute
Dale R. Nyholt: QIMR Berghofer Medical Research Institute
Andrew C. Heath: Washington University, 660S Euclid Avenue
Pamela A. F. Madden: Washington University, 660S Euclid Avenue
Peter M. Visscher: The University of Queensland, Queensland Brain Institute
Margaret J. Wright: QIMR Berghofer Medical Research Institute
Grant W. Montgomery: QIMR Berghofer Medical Research Institute
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Dena Hernandez: Laboratory of Neurogenetics, National Institute on Aging
Stefania Bandinelli: Geriatric Unit, Azienda Sanitaria Firenze (ASF)
Pim van der Harst: University of Groningen, University Medical Center Groningen
Manuela Uda: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato
Peter Vollenweider: Internal Medicine, CHUV, University of Lausanne
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus
Claudia Langenberg: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus
Cornelia van Duijn: Erasmus Medical Center
John Beilby: PathWest Laboratory Medicine of WA
Peter P. Pramstaller: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC)
Andrew A. Hicks: Center for Biomedicine, European Academy of Bolzano/Bozen (EURAC)
Willem H. Ouwehand: University of Cambridge
Konrad Oexle: Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München
Christian Gieger: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstraße 1
Andres Metspalu: Estonian Genome Center, University of Tartu
Clara Camaschella: San Raffaele Scientific Institute
Daniela Toniolo: San Raffaele Scientific Institute
Dorine W. Swinkels: Laboratory of Genetic, Endocrine and Metabolic Diseases (LGEM), Radboud University Medical Centre
John B. Whitfield: QIMR Berghofer Medical Research Institute

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P

Date: 2014
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DOI: 10.1038/ncomms5926

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