Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

Colin C. Pritchard (), Colm Morrissey, Akash Kumar, Xiaotun Zhang, Christina Smith, Ilsa Coleman, Stephen J. Salipante, Jennifer Milbank, Ming Yu, William M. Grady, Jonathan F. Tait, Eva Corey, Robert L. Vessella, Tom Walsh, Jay Shendure and Peter S. Nelson
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Colin C. Pritchard: University of Washington
Colm Morrissey: University of Washington
Akash Kumar: University of Washington
Xiaotun Zhang: University of Washington
Christina Smith: University of Washington
Ilsa Coleman: Fred Hutchinson Cancer Research Center
Stephen J. Salipante: University of Washington
Jennifer Milbank: University of Washington
Ming Yu: Fred Hutchinson Cancer Research Center
William M. Grady: Fred Hutchinson Cancer Research Center
Jonathan F. Tait: University of Washington
Eva Corey: University of Washington
Robert L. Vessella: University of Washington
Tom Walsh: University of Washington
Jay Shendure: University of Washington
Peter S. Nelson: Fred Hutchinson Cancer Research Center

Nature Communications, 2014, vol. 5, issue 1, 1-6

Abstract: Abstract A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsatellite instability (MSI). Mutations are frequently complex MSH2 or MSH6 structural rearrangements rather than MLH1 epigenetic silencing. Our findings identify parallels and differences in the mechanisms of hypermutation in prostate cancer compared with other MSI-associated cancers.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5988

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DOI: 10.1038/ncomms5988

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