SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Michael Van Meter, Mehr Kashyap, Sarallah Rezazadeh, Anthony J. Geneva, Timothy D. Morello, Andrei Seluanov () and Vera Gorbunova ()
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Michael Van Meter: University of Rochester
Mehr Kashyap: University of Rochester
Sarallah Rezazadeh: University of Rochester
Anthony J. Geneva: University of Rochester
Timothy D. Morello: University of Rochester
Andrei Seluanov: University of Rochester
Vera Gorbunova: University of Rochester

Nature Communications, 2014, vol. 5, issue 1, 1-10

Abstract: Abstract L1 retrotransposons are an abundant class of transposable elements that pose a threat to genome stability and may have a role in age-related pathologies such as cancer. Recent evidence indicates that L1s become more active in somatic tissues during the course of ageing; however the mechanisms underlying this phenomenon remain unknown. Here we report that the longevity regulating protein, SIRT6, is a powerful repressor of L1 activity. Specifically, SIRT6 binds to the 5′-UTR of L1 loci, where it mono-ADP ribosylates the nuclear corepressor protein, KAP1, and facilitates KAP1 interaction with the heterochromatin factor, HP1α, thereby contributing to the packaging of L1 elements into transcriptionally repressive heterochromatin. During the course of ageing, and also in response to DNA damage, however, we find that SIRT6 is depleted from L1 loci, allowing the activation of these previously silenced retroelements.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6011

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DOI: 10.1038/ncomms6011

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