Continuous wireless pressure monitoring and mapping with ultra-small passive sensors for health monitoring and critical care

Lisa Y. Chen, Benjamin C. -K. Tee, Alex L. Chortos, Gregor Schwartz, Victor Tse, Darren J. Lipomi, H. -S. Philip Wong, Michael V. McConnell and Zhenan Bao ()
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Lisa Y. Chen: Stanford University
Benjamin C. -K. Tee: Stanford University
Alex L. Chortos: Stanford University
Gregor Schwartz: Stanford University
Victor Tse: Kaiser Permanente
Darren J. Lipomi: Stanford University
H. -S. Philip Wong: Stanford University
Michael V. McConnell: Stanford University
Zhenan Bao: Stanford University

Nature Communications, 2014, vol. 5, issue 1, 1-10

Abstract: Abstract Continuous monitoring of internal physiological parameters is essential for critical care patients, but currently can only be practically achieved via tethered solutions. Here we report a wireless, real-time pressure monitoring system with passive, flexible, millimetre-scale sensors, scaled down to unprecedented dimensions of 1 × 1 × 0.1 cubic millimeters. This level of dimensional scaling is enabled by novel sensor design and detection schemes, which overcome the operating frequency limits of traditional strategies and exhibit insensitivity to lossy tissue environments. We demonstrate the use of this system to capture human pulse waveforms wirelessly in real time as well as to monitor in vivo intracranial pressure continuously in proof-of-concept mice studies using sensors down to 2.5 × 2.5 × 0.1 cubic millimeters. We further introduce printable wireless sensor arrays and show their use in real-time spatial pressure mapping. Looking forward, this technology has broader applications in continuous wireless monitoring of multiple physiological parameters for biomedical research and patient care.

Date: 2014
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DOI: 10.1038/ncomms6028

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