Magneto-fluorescent core-shell supernanoparticles

Ou Chen, Lars Riedemann, Fred Etoc, Hendrik Herrmann, Mathieu Coppey, Mariya Barch, Christian T. Farrar, Jing Zhao, Oliver T. Bruns, He Wei, Peng Guo, Jian Cui, Russ Jensen, Yue Chen, Daniel K. Harris, Jose M. Cordero, Zhongwu Wang, Alan Jasanoff, Dai Fukumura, Rudolph Reimer, Maxime Dahan, Rakesh K. Jain and Moungi G. Bawendi ()
Additional contact information
Ou Chen: Massachusetts Institute of Technology
Lars Riedemann: Massachusetts General Hospital and Harvard Medical School
Fred Etoc: Laboratoire Physico-Chimie Curie, Institut Curie
Hendrik Herrmann: Heinrich-Pette-Institute
Mathieu Coppey: Laboratoire Physico-Chimie Curie, Institut Curie
Mariya Barch: Massachusetts Institute of Technology
Christian T. Farrar: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
Jing Zhao: Massachusetts Institute of Technology
Oliver T. Bruns: Massachusetts Institute of Technology
He Wei: Massachusetts Institute of Technology
Peng Guo: Vascular Biology Program, Children’s Hospital Boston, Harvard Medical School
Jian Cui: Massachusetts Institute of Technology
Russ Jensen: Massachusetts Institute of Technology
Yue Chen: Massachusetts Institute of Technology
Daniel K. Harris: Massachusetts Institute of Technology
Jose M. Cordero: Massachusetts Institute of Technology
Zhongwu Wang: Cornell High Energy Synchrotron Source (CHESS), Wilson Laboratory, Cornell University
Alan Jasanoff: Massachusetts Institute of Technology
Dai Fukumura: Massachusetts General Hospital and Harvard Medical School
Rudolph Reimer: Heinrich-Pette-Institute
Maxime Dahan: Laboratoire Physico-Chimie Curie, Institut Curie
Rakesh K. Jain: Massachusetts General Hospital and Harvard Medical School
Moungi G. Bawendi: Massachusetts Institute of Technology

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle ‘core’, which is fully surrounded by a ‘shell’ of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.

Date: 2014
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DOI: 10.1038/ncomms6093

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