Stimuli-sensitive intrinsically disordered protein brushes

Nithya Srinivasan, Maniraj Bhagawati, Badriprasad Ananthanarayanan and Sanjay Kumar ()
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Nithya Srinivasan: University of California
Maniraj Bhagawati: University of California
Badriprasad Ananthanarayanan: University of California
Sanjay Kumar: University of California

Nature Communications, 2014, vol. 5, issue 1, 1-8

Abstract: Abstract Grafting polymers onto surfaces at high density to yield polymer brush coatings is a widely employed strategy to reduce biofouling and interfacial friction. These brushes almost universally feature synthetic polymers, which are often heterogeneous and do not readily allow incorporation of chemical functionalities at precise sites along the constituent chains. To complement these synthetic systems, we introduce a biomimetic, recombinant intrinsically disordered protein that can assemble into an environment-sensitive brush. This macromolecule adopts an extended conformation and can be grafted to solid supports to form oriented protein brushes that swell and collapse dramatically with changes in solution pH and ionic strength. We illustrate the value of sequence specificity by using proteases with mutually orthogonal recognition sites to modulate brush height in situ to predictable values. This study demonstrates that stimuli-responsive brushes can be fabricated from proteins and introduces them as a new class of smart biomaterial building blocks.

Date: 2014
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DOI: 10.1038/ncomms6145

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