Lymphocytes can self-steer passively with wind vane uropods

Marie-Pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C Lellouch, François Gallet, Sylvie Hénon and Olivier Theodoly ()
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Marie-Pierre Valignat: Laboratory Adhesion & Inflammation, Aix Marseille Université, LAI UM 61
Paulin Nègre: Laboratory Adhesion & Inflammation, Aix Marseille Université, LAI UM 61
Sophie Cadra: Laboratory Adhesion & Inflammation, Aix Marseille Université, LAI UM 61
Annemarie C Lellouch: Laboratory Adhesion & Inflammation, Aix Marseille Université, LAI UM 61
François Gallet: Université Paris-Diderot, CNRS, MSC UMR 7057
Sylvie Hénon: Université Paris-Diderot, CNRS, MSC UMR 7057
Olivier Theodoly: Laboratory Adhesion & Inflammation, Aix Marseille Université, LAI UM 61

Nature Communications, 2014, vol. 5, issue 1, 1-10

Abstract: Abstract A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, suggesting the existence of an adaptive mechano-tranduction mechanism. We find that flow detection may not require molecular mechano-sensors of shear stress, and detection of flow direction can be achieved by the orientation in the flow of the non-adherent cell rear, the uropod. Uropods act as microscopic wind vanes that can transmit detection of flow direction into cell steering via the on-going machinery of polarity maintenance, without the need for novel internal guidance signalling triggered by flow. Contrary to chemotaxis, which implies active regulation of cue-dependent signalling, upstream flow mechanotaxis of lymphocytes may only rely on a passive self-steering mechanism.

Date: 2014
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DOI: 10.1038/ncomms6213

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