Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

Dong-Wook Park, Amelia A. Schendel, Solomon Mikael, Sarah K. Brodnick, Thomas J. Richner, Jared P. Ness, Mohammed R. Hayat, Farid Atry, Seth T. Frye, Ramin Pashaie, Sanitta Thongpang, Zhenqiang Ma () and Justin C. Williams ()
Additional contact information
Dong-Wook Park: University of Wisconsin—Madison
Amelia A. Schendel: Materials Science Program, University of Wisconsin—Madison
Solomon Mikael: University of Wisconsin—Madison
Sarah K. Brodnick: University of Wisconsin—Madison
Thomas J. Richner: University of Wisconsin—Madison
Jared P. Ness: University of Wisconsin—Madison
Mohammed R. Hayat: University of Wisconsin—Madison
Farid Atry: University of Wisconsin—Milwaukee
Seth T. Frye: University of Wisconsin—Milwaukee
Ramin Pashaie: University of Wisconsin—Milwaukee
Sanitta Thongpang: Mahidol University
Zhenqiang Ma: University of Wisconsin—Madison
Justin C. Williams: Materials Science Program, University of Wisconsin—Madison

Nature Communications, 2014, vol. 5, issue 1, 1-11

Abstract: Abstract Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms6258 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6258

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms6258

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().