Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

Romain Banchereau, Nicole Baldwin, Alma-Martina Cepika, Shruti Athale, Yaming Xue, Chun I Yu, Patrick Metang, Abhilasha Cheruku, Isabelle Berthier, Ingrid Gayet, Yuanyuan Wang, Marina Ohouo, LuAnn Snipes, Hui Xu, Gerlinde Obermoser, Derek Blankenship, Sangkon Oh, Octavio Ramilo, Damien Chaussabel, Jacques Banchereau, Karolina Palucka and Virginia Pascual ()
Additional contact information
Romain Banchereau: Baylor Institute for Immunology Research
Nicole Baldwin: Baylor Institute for Immunology Research
Alma-Martina Cepika: Baylor Institute for Immunology Research
Shruti Athale: Baylor Institute for Immunology Research
Yaming Xue: Baylor Institute for Immunology Research
Chun I Yu: Baylor Institute for Immunology Research
Patrick Metang: Baylor Institute for Immunology Research
Abhilasha Cheruku: Baylor Institute for Immunology Research
Isabelle Berthier: Baylor Institute for Immunology Research
Ingrid Gayet: Baylor Institute for Immunology Research
Yuanyuan Wang: Baylor Institute for Immunology Research
Marina Ohouo: Baylor Institute for Immunology Research
LuAnn Snipes: Baylor Institute for Immunology Research
Hui Xu: Baylor Institute for Immunology Research
Gerlinde Obermoser: Baylor Institute for Immunology Research
Derek Blankenship: Baylor Institute for Immunology Research
Sangkon Oh: Baylor Institute for Immunology Research
Octavio Ramilo: Nationwide Children’s Hospital
Damien Chaussabel: Benaroya Research Institute
Jacques Banchereau: Baylor Institute for Immunology Research
Karolina Palucka: Baylor Institute for Immunology Research
Virginia Pascual: Baylor Institute for Immunology Research

Nature Communications, 2014, vol. 5, issue 1, 1-14

Abstract: Abstract The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Exposure of DCs to influenza, Salmonella enterica and Staphylococcus aureus allows us to build a modular framework containing 204 transcript clusters. We use this framework to characterize the responses of human monocytes, monocyte-derived DCs and blood DC subsets to 13 vaccines. Different vaccines induce distinct transcriptional programs based on pathogen type, adjuvant formulation and APC targeted. Fluzone, Pneumovax and Gardasil, respectively, activate monocyte-derived DCs, monocytes and CD1c+ blood DCs, highlighting APC specialization in response to vaccines. Finally, the blood signatures from individuals vaccinated with Fluzone or infected with influenza reveal a signature of adaptive immunity activation following vaccination and symptomatic infections, but not asymptomatic infections. These data, offered with a web interface, may guide the development of improved vaccines.

Date: 2014
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DOI: 10.1038/ncomms6283

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