Genome-wide association study of Arabidopsis thaliana leaf microbial community

Matthew W. Horton, Natacha Bodenhausen, Kathleen Beilsmith, Dazhe Meng, Brian D. Muegge, Sathish Subramanian, M. Madlen Vetter, Bjarni J. Vilhjálmsson, Magnus Nordborg, Jeffrey I. Gordon and Joy Bergelson ()
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Matthew W. Horton: University of Chicago
Natacha Bodenhausen: University of Chicago
Kathleen Beilsmith: University of Chicago
Dazhe Meng: Gregor Mendel Institute, Austrian Academy of Sciences
Brian D. Muegge: Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Sathish Subramanian: Center for Genome Sciences and Systems Biology, Washington University School of Medicine
M. Madlen Vetter: University of Chicago
Bjarni J. Vilhjálmsson: Gregor Mendel Institute, Austrian Academy of Sciences
Magnus Nordborg: Gregor Mendel Institute, Austrian Academy of Sciences
Jeffrey I. Gordon: Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Joy Bergelson: University of Chicago

Nature Communications, 2014, vol. 5, issue 1, 1-7

Abstract: Abstract Identifying the factors that influence the outcome of host–microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.

Date: 2014
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DOI: 10.1038/ncomms6320

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